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Rheumatoid Arthritis (RA)
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Autoimmune
disorder: inflammatory disease leading to irreversible joint
damage, deformity and disability
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Affects 2.5 million
Americans
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50,000 people develop
RA each year; more common in females
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Increased mortality
compared to the general population
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Cause of RA is unknown
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Ref. www.niams.nih.gov
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VGX-1027 |
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New Small Molecule
drug candidate for the treatment of RA
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Orally active
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Showed good preclinical
efficacy against various inflammatory diseases: RA, Type I
Diabetes and inflammatory bowel disease
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The Effects of VGX-1027 on the Development
of Arthritic Score
in Murine Type II Collagen Induced Arthritis |
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0.5
mg i.p. per day for 10 days
As effective as steriod treatment
Dex: dexamethasone |
The Effects of VGX-1027 on Murine
Hind Paw Edema |
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0.5 mg i.p. per day for 10
days |
Type
1 Diabetes |
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Autoimmune disease
that results in the permanent destruction of insulin producing
beta cells in the pancreas.
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Type 1 diabetes
is usually diagnosed in children and young adults, and was
previously known as juvenile diabetes.
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Type 1 diabetes
is treated with insulin replacement therapy- usually by injection
or insulin pump- carbohydrate counting, and careful monitoring
of blood glucose levels using Glucose meters. |
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Untreated diabetes
can lead to one form of diabetic coma, diabetic ketoacidosis,
or even death. |
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There is no cure
for Type 1 diabetes and insulin treatment must be continued
indefinitely. |
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5-10% of North
American diabetics have Type 1. |
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 (in
Mice)
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Mechanism of the action of VGX-1027
against T1D
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In
Type 1 Diabetes (T1D), pro-inflammatory cytokines, such as
TNF-α, Interleukin-1 help to destroy the ß-cell
in pancreas.
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ß-cell destruction
causes inhibition of generation and secretion of insulin.
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This results in
T1D.
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VGX-1027
inhibits the proinflammatory cytokines and prevents the destruction
of ß-cells.
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VGX-1027 helps
ß-cells to recover their function and drops the incidences
of diabetes.
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